HLA-A*23 Is Associated With Lower Odds of Acute Retroviral Syndrome in Human Immunodeficiency Virus Type 1 Infection: A Multicenter Sub-Saharan African Study.

Lindquist L., Kilembe W., Karita E., Price MA., Kamali A., Kaleebu P., Tang J., Allen S., Hunter E., Gilmour J., Rowland-Jones SL., Sanders EJ., Hassan AS., Esbjörnsson J.

The role of human leukocyte antigen (HLA) class I and killer immunoglobulin-like receptor molecules in mediating acute retroviral syndrome (ARS) during human immunodeficiency virus type 1 (HIV-1) infection is unclear. Among 72 sub-Saharan African adults, HLA-A*23 was associated with lower odds of ARS (adjusted odds ratio, 0.10 [95% confidence interval, .01-.48]; P = .009), which warrants further studies to explore its role on HIV-1-specific immunopathogenesis.

DOI

10.1093/ofid/ofae129

Type

Journal article

Journal

Open Forum Infect Dis

Publication Date

04/2024

Volume

11

Keywords

Africa, HLA, KIR, acute HIV infection, acute retroviral syndrome

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