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As a consequence of multidrug resistance, clinicians are highly dependent on fluoroquinolones for treating the serious systemic infection typhoid fever. While reduced susceptibility to fluoroquinolones, which lessens clinical efficacy, is becoming ubiquitous, comprehensive resistance is exceptional. Here we report ofloxacin treatment failure in typhoidal patient infected with a novel, highly fluoroquinolone-resistant isolate of Salmonella enterica serovar Typhi. The isolation of this organism has serious implications for the long-term efficacy of ciprofloxacin and ofloxacin for typhoid treatment.

Original publication




Journal article


Antimicrob Agents Chemother

Publication Date





2761 - 2762


Adolescent, Amino Acid Sequence, Anti-Bacterial Agents, Azithromycin, Bacterial Proteins, DNA Gyrase, Drug Resistance, Multiple, Bacterial, Fluoroquinolones, Humans, Male, Microbial Sensitivity Tests, Molecular Sequence Data, Mutation, Nepal, Ofloxacin, Salmonella typhi, Treatment Failure, Typhoid Fever