Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans , the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been proposed as an experimental platform to explore host-pathogen interactions and evaluate tools for prevention, diagnosis, and treatment. We have previously introduced the use case for a new human model and identified M. ulcerans JKD8049 as a suitable challenge strain. Here, we present a provisional protocol for an initial study, for transparent peer review during the earliest stages of protocol development. Following simultaneous scientific peer review and community/stakeholder consultation of this provisional protocol, we aim to present a refined protocol for institutional review board (IRB) evaluation.
10.12688/wellcomeopenres.22719.2
Journal article
F1000 Research Ltd
2024-10-21T00:00:00+00:00
9
488 - 488
0