Therapeutic and protective efficacy of a dengue antibody against Zika infection in rhesus monkeys
Abbink P., Larocca RA., Dejnirattisai W., Peterson R., Nkolola JP., Borducchi EN., Supasa P., Mongkolsapaya J., Screaton GR., Barouch DH.
Strategies to treat Zika virus (ZIKV) infection in dengue virus (DENV)-endemic areas are urgently needed. Here we show that a DENV-specific antibody against the E-dimer epitope (EDE) potently cross-neutralizes ZIKV and provides robust therapeutic efficacy as well as prophylactic efficacy against ZIKV in rhesus monkeys. Viral escape was not detected, suggesting a relatively high bar to escape. These data demonstrate the potential for antibody-based therapy and prevention of ZIKV.