Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH
Krishnan A., Waheed SO., Varghese A., Cherilakkudy FH., Schofield CJ., Karabencheva-Christova TG.
The second coordination sphere, Asp721, participates in a hydrogen bond with an iron-coordinated water molecule, thus compensating for the missing facial triad carboxylate in AspH and enabling stereoselective C–H oxidation.