Professor Guy Thwaites
Podcast interview
Tuberculosis meningitis
Tuberculosis meningitis affects a fractions of TB patients but causes high levels of mortality and morbidity. A recent trial at OUCRU showed that aspirin can greatly improve outcomes. Such trial is typical of the work done in our Vietnam units, where all the research is focussed on improving the outcome for patients directly.
Colleges
Guy Thwaites
Professor of Infectious Diseases
- Director of Oxford University Clinical Research Unit (OUCRU), Vietnam
OUCRU Vietnam
Guy Thwaites is an academic infectious diseases physician and clinical microbiologist. He has been Director of the Oxford University Clinical Research Unit/Wellcome Programme in Vietnam since October 2013. He is responsible for the scientific strategy of the programme, with its major research themes of emerging viral infections, dengue, brain infections, tuberculosis, malaria, enteric infections, antimicrobial drug resistance and care of the critically ill.
His personal research interests focus on severe bacterial infections, including meningitis and Staphylococcus aureus bloodstream infection, and tuberculosis. He has a longstanding research interest in the diagnosis, treatment and pathophysiology of tuberculous meningitis. Much of his research has been centred on large, pragmatic, randomized controlled trials which have addressed questions of key clinical importance, but have also provided the framework for providing unique insights into disease pathogenesis, antimicrobial pharmacology, and host and bacterial genetics.
Recent publications
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Sotrovimab versus usual care in patients admitted to hospital with COVID-19: a randomised, controlled, open-label, platform trial (RECOVERY)
Journal article
Horby PW. et al, (2025), Lancet Infectious Diseases
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Fatal Mycobacterium avium meningitis in an HIV-negative Vietnamese man: a case report.
Journal article
Nguyen VT. et al, (2025), J Med Case Rep, 19
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Molnupiravir or nirmatrelvir-ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Journal article
RECOVERY Collaborative Group None., (2025), Lancet Infect Dis
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Treatment options to support the elimination of hepatitis C: an open-label, factorial, randomised controlled non-inferiority trial.
Journal article
Cooke GS. et al, (2025), Lancet
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Effectiveness and safety of shortened intensive treatment for children with tuberculous meningitis (SURE): a protocol for a phase 3 randomised controlled trial evaluating 6 months of antituberculosis therapy and 8 weeks of aspirin in Asian and African children with tuberculous meningitis.
Journal article
Huynh J. et al, (2025), BMJ Open, 15