Piero Olliaro
Professor of Poverty Related Infectious Diseases
The background to my professorship in poverty-related infectious diseases lies in the 25 years spent with the Special Programme for Research & Training in Tropical Diseases of the World Health Organization –during which I lead programmes from basic to implementation research on malaria, tuberculosis, and neglected tropical diseases–, including a 17-year visiting professorship with NTM and the Newton-Abraham Professorship in 2014-2015.
I have now joined ISARIC (the International Severe Acute Respiratory and Emerging Infection Consortium) as Director of Science. Our programme primarily aims to accelerate clinical research to prevent illness and deaths from epidemic infectious diseases. While the range of diseases covered is potentially wide, my work currently focusses primarily on plague, Lassa fever, and monkeypox.
One of the features these otherwise very diverse diseases share is the lack of established clinical research methodologies and evidence-based treatments. For instance, for plague –a disease known to have affected humans since the Neolithic and caused hundreds of million deaths– there are cheap, relatively simple treatments, but none has been established based on a randomised clinical trial, the golden standard of medical evidence. For the next three years we will be enrolling patients in a trial in rural Madagascar comparing two regimens for treating plague. If successful it will be the first evidence-based treatment for plague.
Another major area of work for me currently is antimicrobial resistance, whilst also continuing work on other poverty-related infectious diseases such as leishmaniasis, schistosomiasis, soil-transmitted helminthiases, and dengue.
My professional career is shaped by the principle that medical research needs to be public health-driven, and that research capacity strengthening in disease-endemic countries is an integral part of it.
Recent publications
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PP290 Topic: AS03–Disaster Medicine/Trauma, Triage and Transport/Mass Critical Care/Pandemics/Medicine in War Zones/Other: CLINICAL CHARACTERISTICS AND HEALTH OUTCOMES FOR CHILDREN HOSPITALIZED WITH COVID-19
Journal article
Appiah JA. et al, (2024), Pediatric Critical Care Medicine, 25
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Cost-Effectiveness of Test-and-Treat Strategies to Reduce the Antibiotic Prescription Rate for Acute Febrile Illness in Primary Healthcare Clinics in Africa.
Journal article
van Dorst PWM. et al, (2024), Appl Health Econ Health Policy, 22, 701 - 715
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Impact of a package of point-of-care diagnostic tests, a clinical diagnostic algorithm and adherence training on antibiotic prescriptions for the management of non-severe acute febrile illness in primary health facilities during the COVID-19 pandemic in Burkina Faso.
Journal article
Kiemde F. et al, (2024), BMC Infect Dis, 24
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At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods.
Journal article
Mesinovic M. et al, (2024), Sci Rep, 14
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An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus an aminoglycoside + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial-an update to the published protocol.
Journal article
Randremanana RV. et al, (2024), Trials, 25