Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia.
Ramakrishnan G., Wright M., Alam M., Naylor C., Kabir M., Zerin A., Ferdous T., Pedersen K., Hennig BJ., Donowitz JR., Wegmuller R., Haque R., Petri WA., Herbein J., Gilchrist CA.
We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1IU/mL.